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Current Studies & Research
WANTED: Military Veterans, Service Members, and Civilians who have had a Traumatic Brain Injury (TBI)

WANTED: Military Veterans, Service Members, and Civilians who have had a Traumatic Brain Injury (TBI) Request to Take Part in a Study Titled: Treatment for Social Competence in Military Veterans,… Read More

RHI TRANSLATIONAL RESEARCH & ACADEMIC SUMMARY

2013 Translational Research & Academic Summary    IUSM Physical Medicine and Rehabilitation Rehabilitation Hospital of Indiana Indiana TBI Model System Indiana Center for Brain Rehabilitation, Advance Imaging, and Neuroscience (ICBRAIN)… Read More

IU InterFACE Center at Rehabilitation Hospital of Indiana

The IU Interactive and Functional Assessment of Communication and Emotion Center is a natural observation laboratory designed to research emotional and behavioral deficits in people with neurological, psychological, and developmental… Read More

Three RHI clinicians win prestigious awards at the 2013 American Congress of Rehabilitation Medicine (ACRM) conference in Orlando, Florida!

11192013  ACRM Award Press Release Three RHI clinicians win prestigious awards at the 2013 American Congress of Rehabilitation Medicine (ACRM) conference in Orlando, Florida! Flora Hammond, MD, Chief of Medical… Read More

Post-TBI Irritability & Aggression: Building Evidence-Based Approaches to Management

       Flora Hammond, MD (PI), James Malec, PhD (Co-PI), Jacob Kean, PhD, Susan Perkins, PhD, Patrick Monahan, PhD, funded by National Institute on Disability and Rehabilitation Research (NIDRR).   Treatment… Read More

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An Exploration of the Hypocholinergic Hypothesis of Delirium following Traumatic Brain Injury (TBI) February 25th, 2009

Jacob T. Kean, Ph.D., Principal Investigator

Traumatic brain injury (TBI) often causes delirium (confusion and sometimes
agitation) in patients recovering from these types of events. One of the neurochemical
systems that stabilize the brain, the acetylcholine system, often becomes unbalanced
when injuries like this occur, often worsening confusion. We suspect that some drugs that
are used with these kinds of injuries create further imbalances in this system.
Currently Dr. Jacob Kean is conducting a study to determine whether a specific class of
drugs (anticholinergic) could be aggravating this imbalance in these patients. Should
this study point to a connection between some of these drugs and the imbalance of the
acetylcholine system, it could suggest better outcomes may be achieved by limiting
the use of these drugs in patients with brain injuries, including reducing confusion and
potentially enhancing the speed of recovery.